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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $68 | 5 days |
Description | ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50 values of 18.93 μM for purified CcO from human glioma and 31.82 μM for CcO from bovine heart. |
In vitro | ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, exhibiting IC50 values of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 also inhibits CcO activity in UTMZ and Jx22-derived GSCs with IC50 values of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM, respectively. At a concentration of 25 μM, ADDA 5 shows a growth inhibitory effect on UTMZ cells, with an EC50 of 8.17 μM[1]. |
In vivo | ADDA 5 demonstrates no detectable toxicity in mice at dosages up to 80 mg/kg [1]. At a concentration of 8 mg/kg, administered intraperitoneally (i.p.), it significantly inhibits tumor growth in mice. |
Molecular Weight | 406 |
Formula | C24H36ClNO2 |
Cas No. | 473268-46-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 65 mg/mL (160.10 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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