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ADDA 5 hydrochloride

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ADDA 5 hydrochloride

Catalog No. T14126Cas No. 473268-46-1

ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50 values of 18.93 μM for purified CcO from human glioma and 31.82 μM for CcO from bovine heart.

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Pack Size	Price	Availability	Quantity
2 mg	$68	5 days

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Product Introduction

Bioactivity

Description	ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50 values of 18.93 μM for purified CcO from human glioma and 31.82 μM for CcO from bovine heart.
In vitro	ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, exhibiting IC50 values of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 also inhibits CcO activity in UTMZ and Jx22-derived GSCs with IC50 values of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM, respectively. At a concentration of 25 μM, ADDA 5 shows a growth inhibitory effect on UTMZ cells, with an EC50 of 8.17 μM[1].
In vivo	ADDA 5 demonstrates no detectable toxicity in mice at dosages up to 80 mg/kg [1]. At a concentration of 8 mg/kg, administered intraperitoneally (i.p.), it significantly inhibits tumor growth in mice.

Chemical Properties

Molecular Weight	406
Formula	C24H36ClNO2
Cas No.	473268-46-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 65 mg/mL (160.10 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4631 mL	12.3153 mL	24.6305 mL	123.1527 mL
5 mM	0.4926 mL	2.4631 mL	4.9261 mL	24.6305 mL
10 mM	0.2463 mL	1.2315 mL	2.4631 mL	12.3153 mL
20 mM	0.1232 mL	0.6158 mL	1.2315 mL	6.1576 mL
50 mM	0.0493 mL	0.2463 mL	0.4926 mL	2.4631 mL
100 mM	0.0246 mL	0.1232 mL	0.2463 mL	1.2315 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ADDA5 HydrochlorideADDA 5 hydrochlorideADDA 5 HydrochlorideADDA-5 Hydrochloride